Rejuran PDRN Skin Treatment
Salmon DNA Polynucleotide Therapy for Deep Skin Regeneration & Rejuvenation
- ExpertiseTop 1%Injector in the country
- ExperienceOver 11,000Patients treated
- Excellence590+Five star reviews
Why Choose Dr. Avaliani for Rejuran PDRN?
Rejuran PDRN represents a breakthrough in skin regeneration technology, using polydeoxyribonucleotides (PDRN) derived from salmon DNA, which shares 97% similarity with human DNA. This innovative treatment promotes collagen production, stimulates fibroblast activity, and supports natural cell regeneration at the deepest level. The result is visibly healthier, more hydrated, and more youthful skin from the inside out.
DNA-Based Science
PDRN technology uses greater than 95% pure DNA fragments from wild salmon reproductive cells, processed with DOT™ (DNA Fragments Optimizing Technology) for maximum biocompatibility and cellular regeneration
Board-Certified Physician
11+ years of aesthetic medicine experience. Dr. Avaliani was among the first providers in NYC to offer Rejuran PDRN and personally administers every treatment
Minimal Downtime
Minimal downtime: redness and dryness typically resolve within 2 hours, with most patients returning to normal activities the same day
A Reputation Built on Results
5.0-star rating with 565+ verified patient reviews and proven skin rejuvenation outcomes with visibly healthier, more luminous skin
Personalized Approach
Customized treatment plans using the right Rejuran formulation and delivery method for your specific skin concerns and goals
What Is Rejuran PDRN?
PDRN stands for PolyDeoxyRiboNucleotides, a DNA structure component derived from salmon DNA that shares 97% similarity with human DNA. Rejuran products use wild Korean salmon reproductive cells processed with PharmaResearch’s DOT™ technology for greater than 95% purity. When delivered into the skin, PDRN promotes collagen production, stimulates fibroblast activity, and supports natural cell regeneration for deep, lasting skin improvement.
At Dr. Avaliani’s practice, Rejuran PDRN is delivered using advanced techniques for maximum penetration and effectiveness. The treatment is often combined with microneedling or fractional laser technologies like Genius RF, ICON, or PicoSure Focus to enhance product absorption deep into the dermal layer. This combination approach accelerates recovery 50-70% faster than laser alone while delivering superior skin regeneration results.
How Rejuran PDRN Works
Rejuran PDRN therapy follows a science-based protocol:
- Dr. Avaliani evaluates your skin quality and selects the optimal Rejuran formulation for your concerns
- PDRN polynucleotides are delivered into the skin via microneedling or laser-assisted absorption
- The DNA fragments activate fibroblasts and stimulate natural collagen and elastin production at the cellular level
- Skin regeneration occurs from within as new collagen forms, hydration improves, and damaged cells are repaired
- Over a series of treatments spaced 2-4 weeks apart, skin becomes progressively brighter, smoother, and more resilient
Conditions We Treat with Rejuran
Fine Lines & Wrinkles
Crow’s feet, forehead lines, and fine wrinkles across the face. PDRN stimulates collagen and elastin production at the cellular level, gradually smoothing fine lines and restoring the skin’s natural elasticity and firmness from within.
Under-Eye Rejuvenation
Dark circles, thin skin, and crepiness under the eyes. Rejuran’s regenerative properties improve skin thickness, texture, and hydration in the delicate periorbital area, reducing the appearance of hollows and darkness without filler.
Dull & Dehydrated Skin
Skin that has lost its natural glow and appears dry, lackluster, or tired. PDRN deeply rehydrates the skin and promotes fibroblast activity, restoring the luminous, healthy complexion that comes from genuine cellular regeneration rather than surface-level hydration.
Acne Scars & Skin Texture
Uneven skin texture, enlarged pores, and post-acne scarring. When combined with microneedling or fractional lasers, Rejuran PDRN enhances the skin’s healing response, accelerating collagen remodeling for smoother, more refined skin texture.
Hyperpigmentation
Sun spots, melasma, and uneven skin tone. The Rejuran Tone-Up Booster combines PDRN with tranexamic acid, glutathione, and vitamin C to brighten darkened areas and reduce hyperpigmentation while simultaneously regenerating the skin.
Post-Laser Recovery
Accelerated healing after laser skin resurfacing, microneedling, or chemical peels. PDRN’s anti-inflammatory properties speed up post-procedure recovery by 50-70%, reducing redness and downtime while enhancing the regenerative results of the primary treatment.
Our Rejuran Products
Three specialized Rejuran formulations for targeted skin regeneration:
Rejuran Healing Essence
Contains 2.0% hydrolyzed DNA polynucleotide, the highest concentration in the Rejuran line. This professional-grade formulation delivers maximum PDRN to the skin for comprehensive regeneration, collagen stimulation, and deep hydration. Ideal for overall skin rejuvenation and anti-aging treatment.
Rejuran Skin Booster
A two-vial system that combines 1.0% hydrolyzed DNA with hyaluronic acid and amino acids. This formulation provides both PDRN regeneration and deep hydration in a single treatment. The combination of polynucleotides and HA delivers immediate plumping along with long-term cellular repair.
Rejuran Tone-Up Booster
A specialized brightening formulation that combines PDRN with tranexamic acid, glutathione, and vitamin C. Targets hyperpigmentation, dark spots, and uneven skin tone while simultaneously regenerating the skin. Ideal for melasma, sun damage, and darkened areas like elbows and knees.
Call us today to schedule your Rejuran PDRN consultation with Dr. Avaliani and discover the future of skin regeneration!
Does It Hurt?
Your comfort options (we tailor this to you)
Rejuran PDRN treatment is comfortable and well tolerated. When delivered via microneedling, topical numbing cream is applied beforehand. When combined with laser treatments, the PDRN actually accelerates healing and reduces discomfort. Most patients describe the experience as very manageable, and Pro-Nox (nitrous oxide) is available for additional comfort.
Downtime is minimal. Redness and mild dryness typically resolve within 2 hours. When combined with laser procedures, PDRN’s anti-inflammatory properties speed recovery by 50-70% compared to laser alone. Dr. Avaliani recommends waiting 24 hours before applying makeup and avoiding strenuous exercise for the first day.
Feel Calm. Stay in Control. Look Amazing.
Learn about your comfort options ›- Reduced anxietySettle into a calm, relaxed state before and during your treatment, with no stress and no tension.
- Less discomfortEnhanced comfort for your treatment, so you can focus on your results.
- No downtimeWalk out feeling great and drive yourself home. No recovery time required.
Is Rejuran PDRN Right for Me?
Ideal Candidates
You may be a good candidate if you:
- Want to improve overall skin quality, hydration, and luminosity from within
- Have fine lines, wrinkles, or loss of skin elasticity
- Have dark circles or thin skin under the eyes
- Have hyperpigmentation, sun damage, or uneven skin tone
- Want to enhance recovery after laser or microneedling treatments
- Are looking for a science-based approach to deep skin regeneration
What Does Rejuran PDRN Cost?
Pricing Information
The cost of Rejuran PDRN therapy depends on the product type selected, the treatment area, and the number of sessions in your protocol. Price Range: Treatments are typically spaced 2-4 weeks apart, with maintenance every 3 to 12 months depending on skin quality During your consultation, Dr. Avaliani will evaluate your skin, discuss your goals, and recommend the optimal Rejuran formulation and delivery method with transparent pricing. A series of treatments delivers the best results, with progressive improvement in skin quality after each session.
View before & after gallery
Results vary from patient to patient. The gallery shows real outcomes from treatments performed by Dr. Avaliani.
Before and after imagery to be added for this treatment.
Rejuran PDRN Skin Treatment frequently asked questions
What is PDRN and how does it work?
PDRN stands for PolyDeoxyRiboNucleotides, DNA fragments derived from salmon that share 97% similarity with human DNA. When delivered into the skin, these fragments activate fibroblasts, stimulate collagen and elastin production, and promote natural cell regeneration. The result is healthier, more hydrated, and more youthful skin from within.
Why salmon DNA?
Korean wild salmon reproductive cells contain DNA with 97% similarity to human DNA, making them highly biocompatible. PharmaResearch’s DOT™ technology processes these cells to greater than 95% purity without surfactants, creating the purest and most effective PDRN formulation available.
How many treatments will I need?
Most patients benefit from a series of treatments spaced 2 to 4 weeks apart. The number of sessions depends on your skin concerns and goals. Maintenance treatments are recommended every 3, 6, or 12 months depending on your skin quality. Results are cumulative and improve with each session.
Is there any downtime?
Downtime is minimal. Redness and mild dryness typically resolve within 2 hours. When Rejuran is combined with laser treatments, its anti-inflammatory properties actually speed up recovery by 50-70%. Wait 24 hours before applying makeup and avoid strenuous exercise for the first day.
What areas can Rejuran treat?
Rejuran PDRN can be applied anywhere on the body. Common treatment areas include the face (fine lines, wrinkles, overall rejuvenation), under-eye area (dark circles, thin skin), neck, chest, hands, and even body areas like elbows and knees for brightening darkened skin.
What is the difference between the three Rejuran products?
Rejuran Healing Essence contains 2.0% PDRN for maximum regeneration. Rejuran Skin Booster combines 1.0% PDRN with hyaluronic acid and amino acids for regeneration plus hydration. Rejuran Tone-Up Booster adds tranexamic acid, glutathione, and vitamin C for brightening and pigmentation correction.
Can Rejuran be combined with other treatments?
Yes. Rejuran is frequently combined with microneedling, fractional lasers (Genius RF, ICON, PicoSure Focus), and other skin treatments. PDRN enhances post-procedure healing and boosts the regenerative results of these treatments. Dr. Avaliani often designs combination protocols for maximum benefit.
Is Rejuran safe?
Yes. Rejuran PDRN has been extensively studied and used in Korea for years with an excellent safety profile. The salmon-derived polynucleotides are processed to greater than 95% purity using DOT™ technology. The treatment is biocompatible and well-tolerated with no significant side effects reported.
When will I see results?
Many patients notice improved skin hydration and glow within the first few days. Collagen remodeling and deeper structural improvements develop over 2 to 4 weeks following each session. Results are cumulative, with progressively better skin quality after each treatment in the series.
How is Rejuran different from regular skin boosters?
Traditional skin boosters primarily provide hydration through hyaluronic acid. Rejuran goes much deeper: its PDRN fragments activate your skin’s own regenerative machinery, stimulating fibroblasts to produce new collagen and elastin. This creates genuine cellular-level improvement rather than just surface hydration.
Luxury treatments. Flexible payment options.
Exceptional aesthetic care should be available when you are ready. We offer financing that lets you begin treatment now and manage the cost over time.
